Induces Degradation of Myosin Heavy Chain via p38 MAPK and Muscle-Specific E3 Ubiquitin Ligases in C2 Skeletal Myotubes

Fig. 1 Effects of ONOO− on viability of myotubes. Myotubes were exposed to 25 μM ONOO− for 1, 2, and 6 h. Untreated myotubes served as control (CTL). Following incubation, viability of myotubes was assessed by the MTT assay. Results are means ± SE of 3 independent experiments. 3.2 ONOO− Activates p38 MAPK p38 MAPK…

This study investigated the role that the E2 ubiquitin conjugating enzyme, UBE2L3, plays in skeletal muscle wasting through its differential interaction with f-actin, g-actin, and myosin heavy chain.

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Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro

Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice

Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β - ScienceDirect

Frontiers Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis

Myosin heavy chain is stabilized by BCL-2 interacting cell death suppressor (BIS) in skeletal muscle

The involvement of the ubiquitin proteasome system in human skeletal muscle remodelling and atrophy - ScienceDirect

Myosin heavy chain is stabilized by BCL-2 interacting cell death suppressor (BIS) in skeletal muscle

Tumor cell anabolism and host tissue catabolism-energetic inefficiency during cancer cachexia - Mangala Hegde, Uzini Devi Daimary, Sosmitha Girisa, Aviral Kumar, Ajaikumar B Kunnumakkara, 2022

Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β - ScienceDirect

ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation

Cancer cachexia: molecular mechanisms and treatment strategies, Journal of Hematology & Oncology